Welcome to the Burstyn-Cohen lab
The labs interest lies in how our cells and tissues maintain homeostasis, which is necessary for proper health and function. We study the role of TAM (Tyro3, AXL, MERTK) receptors and their ligands PROS1 and GAS6 in various aspects of tissue homeostasis. Loss of TAM function affects the immune, nervous, vascular and reproduction systems, while their gain of function is tumor-promoting. We use cell culture, biochemical and transgenic mouse approaches to understand their role in the nervous system (including neural stem cells and microglia), the eye and immune cells. We utilize various cancer models to understand their roles in cancer in disease. Additionally, we are interested in understanding the molecular basis for the functional diversity displayed by TAMs and their ligands.